Citation

Malca Garcia GR, Hennig L, Shelukhina IV, Kudryavtsev DS, Bussmann RW, Tsetlin VI, Giannis A. J. Nat. Prod. 2015; 78(11): 2537-2544.

Affiliation

Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig , Johannisallee 29, 04103 Leipzig, Germany.

Copyright

(Copyright © 2015, American Society of Pharmacognosy)

DOI

10.1021/acs.jnatprod.5b00457

PMID

26496427

Abstract

A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of d-(-)-quinic acid, l-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1-5. d-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11'. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1-3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.

Language: en