Citation

García-Algar O, Cuadrado González A, Falcon M. An. Pediatr. 2015; 85(3): 160.e1-1604.

Vernacular Title

Utilidad del cribado toxicológico en pediatría.

Affiliation

Grup de Recerca Infància i Entorn (GRIE), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona; Red de Salud Materno Infantil y del Desarrollo (SAMID), Retics, Instituto de Salud Carlos III, Madrid, España; Departamento de Medicina Legal, Universidad de Murcia, Murcia, España.

Copyright

(Copyright © 2015, Asociacion Espanola de Pediatria, Publisher Elsevier Publishing)

DOI

10.1016/j.anpedi.2015.07.036

PMID

26458521

Abstract

The prevalence of acute or chronic exposure to substances of abuse in paediatric patients, from the neonatal period to adolescence, is not well established as most cases go unnoticed. Regardless of clinical cases of acute poisoning leading to visits to emergency room, the exposure is usually detected by a questionnaire to the parents or children. In the last few years, new validated analytical methodologies have been developed in order to detect parent drugs and their metabolites in different biological matrices. These biological matrices have different time windows for detection of the exposure: acute (i.e., urine, blood, oral fluid), and chronic (i.e., hair, meconium or teeth). The aim of this paper was to review the scenarios where the use of biological matrices is indicated for the detection of acute or chronic exposure to substances of abuse.

Language: es