Citation

Rahmani A, Hatefi M, Bezadi S, Moghadas Dastjerdi M, Zare M, Imani A, Shirazi D. World Neurosurg. 2015; 87: 507-515.

Affiliation

General medicine, Student research committee, school of medicine, Ilam University of medical science, Ilam, Iran.

Copyright

(Copyright © 2015, Elsevier Publishing)

DOI

10.1016/j.wneu.2015.09.016

PMID

26386458

Abstract

BACKGROUND: Effective clinical variables are required for determining the severity of trauma and prognosis in patients with Traumatic Brain Injury (TBI).The aim of the present study was to examine the relationship between homocysteine (Hcy) plasma levels and prognosis of TBI patients MATERIALS AND METHODS: In a prospective case- control study, all demographic, clinical and Glasgow Coma Scale (GCS) data were collected. Prognosis was evaluated according to Glasgow Outcome Scale (GOS) at the time of discharge from hospital and 6 months after hospitalization. The levels of Hcy plasma were measured using the High Performance Liquid Chromatography (HPLC) tool. The Computed Tomography (CT) scan of the brain was performed in the first 24 hours of hospitalization.

RESULTS: In this study, 150 TBI patients as a case group (male, 54.7%, mean age, 55.90±12.31) and 150 healthy persons as a control group (male, 52%, mean of age, 49.56±15.64) were studied. The mean ± SD plasma Hyc level in TBI patients (20.91±15.56μmol/L) was significantly higher than that of the control group (7.45±13.54 μmol/L, P =0.000).There was a significant relationship between the Hyc plasma levels and GCS and CT findings classified by the Marshall score. (P =0.001 and P =0.028, respectively).Also, there was a significant difference in the mean Hcy plasma between dead and alive patients according to GOS (P=0.000 and P = 0.054, respectively).

CONCLUSION: According to the results of this study, there was a significant correlation between the plasma Hcy levels and severity of trauma and prognosis in patients with TBI.

Language: en