Citation

Tanner SB, Harwell SA. Ther. Adv. Musculoskelet. Dis. 2015; 7(4): 152-159.

Affiliation

Vanderbilt University Medical Center - Rheumatology, 1161 21st Avenue So., T-3113 MCN, Nashville, Tennessee 37232, USA.

Copyright

(Copyright © 2015, SAGE Publishing)

DOI

10.1177/1759720X15588521

PMID

26288665

PMCID

PMC4530385

Abstract

Vitamin D has known importance to bone health including calcium and phosphate homeostasis and appears to have a role in skeletal muscle health as well. Cases of vitamin D deficiency and insufficiency have been associated with poor muscle health. While the exact effects and mechanism of action remains controversial, current data lean towards insufficient vitamin D playing a role in musculoskeletal pain, sarcopenia, myopathy, falls and indirectly via cerebellar and cognitive dysfunction. Sophisticated experimental techniques have allowed detection of the vitamin D receptor (VDR) on skeletal muscle and cerebellar tissue, which if validated in further large studies, could confirm the mechanism of vitamin D in these associations. While further study is required, vitamin D repletion can have a substantial impact on muscle as well as bone health.

Language: en