Citation

Wijayatilake DS, Sherren PB, Jigajinni SV. Curr. Opin. Anaesthesiol. 2015; 28(5): 525-531.

Affiliation

aDepartment of Neurointensive Care, Queens Hospital, BHR NHS Trust, Romford bQueen Mary's University of London cDepartment of Anaesthesiology, Intensive Care Medicineand Prehospital Emergency Medicine, London's Air Ambulance, RoyalLondon Hospital, London dDepartment of Anesthesiology, Queens Hospital, BHR NHS Trust, Romford, UK.

Copyright

(Copyright © 2015, Lippincott Williams and Wilkins)

DOI

10.1097/ACO.0000000000000236

PMID

26280821

Abstract

PURPOSE OF REVIEW: Increased understanding of the pathophysiology in traumatic brain injury (TBI) has resulted in the development of core physiological targets and therapies to preserve cerebral oxygenation, and in doing so prevent secondary insult. This review addresses the many systemic complications of TBI that make achieving these targets challenging and can influence outcome. RECENT FINDINGS: There are a wide range of systemic complications following TBI. Complications involve the cardiovascular, respiratory, immunological, haematological and endocrinological systems amongst others, and can influence early management and long-term outcomes. SUMMARY: Effective management of TBI should go beyond formulaic-based pursuit of physiological targets and requires a detailed understanding of the multisystem response of the body.

Language: en