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Citation |
Perkins MW, Wong B, Rodriguez A, Devorak J, Sciuto AM. Inhal. Toxicol. 2015; 27(9): 432-439. |
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Affiliation |
Analytical Toxicology Division, US Army Medical Research Institute of Chemical Defense , Aberdeen Proving Ground, MD , USA. |
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Copyright |
(Copyright © 2015, Informa - Taylor and Francis Group) |
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DOI |
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PMID |
26207672 |
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Abstract |
Respiratory dynamics were investigated in head-out plethysmography chambers following inhalational exposure to soman [also, GD, an extremely toxic nerve agent] in untreated, non-anesthetized rats. A multipass saturator cell was used to generate 520, 560 and 600 mg × min/m(3) of soman vapor in a customized inhalational exposure system. Various respiratory dynamic parameters were collected from male Sprague-Dawley rats (300--350 g) during (20 min) and 24 h (10 min) after inhalational exposure. Signs of CWNA-induced cholinergic crisis were observed in all soman-exposed animals. Percentage body weight loss and lung edema were observed in all soman-exposed animals, with significant increases in both at 24 h following exposure to 600 mg × min/m(3). Exposure to soman resulted in increases in respiratory frequency (RF) in animals exposed to 560 and 600 mg × min/m(3) with significant increases following exposure to 560 mg × min/m(3) at 24 h. No significant alterations in inspiratory time (IT) or expiratory time (ET) were observed in soman-exposed animals 24 h post-exposure. Prominent increases in tidal volume (TV) and minute volume (MV) were observed at 24 h post-exposure in animals exposed to 600 mg × min/m(3). Peak inspiratory (PIF) and expiratory flow (PEF) followed similar patterns and increased 24 h post-exposure to 600 mg × min/m(3) of soman. Language: en |