|
Abstract
|
AIM: We report here, case series of patients with acute kidney injury (AKI) after ingestion of Paraphenylene diamine (PPD) a derivative of analine. It is used as coloring agent to dye hair, fur and plastic and in photographic films.
PATIENTS AND METHODS: subjects for the study reported here comprised a cohort of100 patients coming to this institution with AKI following PPD poisoning. AKI was defined according to RIFLE criteria and PPD poisoning on basis of history and presenting features. All patients had normal size kidneys on ultrasonography and no previous co- morbidity.
RESULTS: One hundred patients with AKI after PPD exposure were brought to this institute between May 2010- February.2015, among these 56 were females, with mean age of 23.11 ± 7.94 years. Cause of AKI was toxic rhabdomyolysis as indicated by marked rise in muscle enzymes with mean LDH and CK levels of 6665.22±6272.04 and 194486.66±301905.80 respectively. Hepatotoxicity with raised AST and ALT was a main feature of the studied population. Renal replacement was required in 97 % patients. Complete renal recovery was observed in 77 patients, while 16 died during acute phase of illness. Respiratory failure and recurrent hyperkalemia were main causes of mortality.
CONCLUSION: Easy availability and low cost of PPD, lead to remarkable increase in use of the substance, especially for suicidal purpose. Awareness among health professionals and at society as well as government level is need of time.
Language: en |