Citation

Lee M, Eyer F, Felgenhauer N, Klinker HH, Spinner CD. AIDS Res. Ther. 2015; 12: 18.

Affiliation

Department of Medicine II and Interdisciplinary HIV Center (IZAR), University Hospital Klinikum Rechts Der Isar, Technische Universität München, Ismaningerstr. 22, Munich, 81675 Germany.

Copyright

(Copyright © 2015, Holtzbrinck Springer Nature Publishing Group - BMC)

DOI

10.1186/s12981-015-0054-y

PMID

26045712

PMCID

PMC4455705

Abstract

A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to levels measured prior to the intoxication. No other adverse events occurred, and the patient does not suffer from permanent impairments.

Language: en