Citation

Geng Y, Peng N, Li XG, Liu YN, Li BL, Peng LQ, Ma Q, Su L. Shock 2015; 44(2): 149-156.

Affiliation

1Department of Gastroenterology, 303 Hospital of People's Liberation Army of China, Nanning 530021, P.R. China 2Department of Intensive Care Unit, General Hosiptal of GuangZhou Military Command, GuangZhou 510010, P. R. China 3Department of Graduate School, Southern Medical University, Guangzhou 510515, P. R. China 4Department of Neurology, Fifth People's Hospital of Chongqing. Chongqing 400062, P.R. China. 5State Key Laboratory of Organ Failure Research, Institute of Antibody Engineering, Southern Medical University, Guangzhou 510515, P. R. China.

Copyright

(Copyright © 2015, The Shock Society, Publisher Lippincott Williams and Wilkins)

DOI

10.1097/SHK.0000000000000387

PMID

26009815

Abstract

Animals suffering from heatstroke (HS) following physical effort may have different heat-related core temperature (Tc) responses compared with passive HS. In the present study, conscious and unrestrained rats were exposed to ambient temperature (Ta) of 39.5 ± 0.2°C with or without running (run-heated or rest-heated, respectively) until HS onset, which was defined as the systolic blood pressure (SBP) starting to drop. In comparison with rest-heated rats, run-heated rats had a significantly shorter latency of HS onset. Physical effort did not have significant influence on hyperthermia severity (43.3±0.2°C at rest-heated, and 43.4±0.2°C at run-heated), but it could significantly decrease the thermal load to develop HS (315.1±37.3°C[BULLET OPERATOR]min for rest-heated, and 133.5±21.4°C[BULLET OPERATOR]min for run-heated). Working component during heat exposure may contribute to a decreased survival rate of HS (46.9% at rest-heated, and 31.3% at run-heated). Impaired heat dissipation during recovery may be the responsible for relative poor survival of run-heated rats. In both groups, survival was affected by Tc,HS and thermal area. Hypothermia (Tc <35°C) developed after HS onset, with no significant difference in Tc,min between the rest-heated and run-heated groups. These thermoregulatory responses to HS after physical effort may provide insight into HS pathophysiology.

Language: en