Citation

Coccaro EF, Fanning JR, Phan KL, Lee R. CNS Spectr. 2015; 20(3): 295-302.

Affiliation

1Clinical Neuroscience & Psychopharmacology Research Unit,Department of Psychiatry (MC#3077),Pritzker School of Medicine,University of Chicago,Chicago,Illinois,USA.

Copyright

(Copyright © 2015, MBL Communications)

DOI

10.1017/S1092852915000310

PMID

25997605

Abstract

Aggression is a behavior with evolutionary origins, but is often both destructive and maladaptive in today's society. Research over the past several decades has confirmed the involvement of neurotransmitter function in aggressive behavior. This research has centered around the "serotonin hypothesis." As this literature continues to grow, guided by pre-clinical research and aided by the application of increasingly sophisticated neuroimaging methodology, a more complex picture has emerged. As current pharmacological and therapeutic interventions are effective but imperfect, it is hoped that new insights into the neurobiology of aggression will reveal novel avenues for treatment of this destructive and costly behavior.

Language: en