Citation

Zagar T, Jerman B, Paragi M, Sugden K, Craig IW, Farmer A, Zorko M, Roskar S, Kravanja M, Balazic O, Balazic J, Marusic A. Psychiatr. Danub. 2006; 18(Suppl 1): 74.

Affiliation

Institute of Public Health of the Republic of Slovenia, Trubarjeva 2, 1000 Ljubljana, Slovenia. tina.zagar@ivz-rs.si.

Copyright

(Copyright © 2006, Facultas Universitatis Studiorum Zagrabiensis - Danube Symposion of Psychiatry)

DOI

unavailable

PMID

16963981

Abstract

Background: Suicidal behavior has been associated with dysfunction of genes responsible for the serotonergic system. Aims: To determine genetic risk factors for completed suicide in a case-control study and investigate correlations with other relevant factors. Method: The DNA analyses included three single nucleotide polymorphisms (SNP) and microsattelite in TPH1. We also analysed an insertion/deletion in the promoter region (HTTLPR) and VNTR2 in the serotonin transporter gene (HTT), one SNP in the receptor HTR2A and another SNP in receptor HT1B, all genes related to the serotonergic neurotransmission. The last investigation was VNTR within gene for MAOA, referring to serotonin catabolism. All analyses were done on 224 suicide victims, who committed suicide using different violent or non-violent methods, on 146 of their matched controls and on patients with depression, but without suicidal behaviour. Results: The main findings of our study was an association between the absence of TPH1 188 allele and completed suicide. Furthermore, associations between the TPH1 A779C and MAOA and suicide victims older than 48 years has been obtained. The latest results of gene-environment interactions will be presented. Conclusion: Our results indicate the influence of other variables, like age and gender as possible covariants of genetic risk factors for completed suicide in Slovenia.

Language: en