Citation

Giegling I, Hartmann AM, Moller HJ, Rujescu D. Psychiatr. Danub. 2006; 18(Suppl 1): 74.

Affiliation

University of Munich LMU, Molecular and Clinical Neurobiology, Nussbaumstr 7, 80336 Munich, Germany. Ina.giegling@med.uni-muenchen.de.

Copyright

(Copyright © 2006, Facultas Universitatis Studiorum Zagrabiensis - Danube Symposion of Psychiatry)

DOI

unavailable

PMID

16963982

Abstract

Risk of suicide-related behavior is supposed to be determined by a complex interplay of sociocultural factors, traumatic life experiences, psychiatric history, personality traits, and genetic vulnerability. Family and twin studies point towards a partial heritability of suicidal behavior and aggression-related traits. We have initiated a large scale case control genetic association study which comprises of 250 suicide attempters and 1600 healthy volunteers and investigated the role of a comprehensive set of candidate genes in this behavior. We will present new data on the MAO A and MAO B genes as candidate genes for these traits. We studied several gene variants of MAO A and MAO B in a sample of 571 suicide attempters, healthy controls and suicide completers. We also analyzed the relation to aggression-related traits, assessed by STAXI and FAF. Our results provide evidence that the MAO A and MOA B may influence aggression-related traits. Given that these represent intermediate phenotypes of suicidal behavior, MAO A and MAO B might also act on suicidal behavior through these traits. The observed associations warrant further replications.

Language: en