Citation

West JB. J. Physiol. 2015; 594(5): 1127-1134.

Affiliation

Department of Medicine, University of California San Diego, La Jolla, CA, 92093-0623, USA.

Copyright

(Copyright © 2015, The Physiological Society, Publisher John Wiley and Sons)

DOI

10.1113/JP270284

PMID

25962370

Abstract

Barcroft's bold assertion that everyone at high altitude has physical and mental impairment compared with sea level was very provocative. It was a result of the expedition that he led to Cerro de Pasco in Peru, altitude 4300 m. Although it is clear that newcomers to high altitude have reduced physical powers, some people believe that this does not apply to permanent residents who have been at high altitude for generations. The best evidence supports this contention although permanent residents often perform better than acclimatized lowlanders. Turning to neuropsychological function, newcomers to high altitude certainly have some impairment, and there is evidence that the same applies to highlanders. However the notion that permanent residents are impaired is an anathema to many people. For example the eminent Peruvian physician, Carlos Monge, took great exception to Barcroft's remark and even attributed it to the fact that Barcroft was suffering from Acute Mountain Sickness when he made it! Monge referred to "Climatic Aggression" by which he meant the negative consequences of the inevitable hypoxia of high altitude. Recent technological advances such as oxygen enrichment of room air can overcome this "aggression". This might be useful in some settings at high altitude such as a nursery where newborn babies are cared for, and possibly operating rooms where the surgeon's dexterity may be enhanced. Other situations might be dormitories, conference rooms, and perhaps some school rooms. These constitute possible ways by which the effects of Barcroft's assertion might be countered. This article is protected by copyright. All rights reserved.

Language: en