Citation

Vinck M, Batista-Brito R, Knoblich U, Cardin JA. Neuron 2015; 86(3): 740-754.

Affiliation

Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Kavli Institute of Neuroscience, Yale University, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: jess.cardin@yale.edu.

Copyright

(Copyright © 2015, Cell Press)

DOI

10.1016/j.neuron.2015.03.028

PMID

25892300

Abstract

Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a change in arousal levels. We recorded single cells and local field potentials from area V1 in mice head-fixed on a running wheel and monitored pupil diameter to assay arousal. Using naturally occurring and induced state transitions, we dissociated arousal and locomotion effects in V1. Arousal suppressed spontaneous firing and strongly altered the temporal patterning of population activity. Moreover, heightened arousal increased the signal-to-noise ratio of visual responses and reduced noise correlations. In contrast, increased firing in anticipation of and during movement was attributable to locomotion effects. Our findings suggest complementary roles of arousal and locomotion in promoting functional flexibility in cortical circuits.

Language: en