Citation

Kim KW, Won YL, Ko KS. Toxicol. Res. 2015; 31(1): 25-32.

Affiliation

Occupational Safety and Health Research Institute, KOSHA, Ulsan, Korea.

Copyright

(Copyright © 2015, Korean Society of Toxicology)

DOI

10.5487/TR.2015.31.1.025

PMID

25874030

Abstract

The objectives of this study were to investigate the individual characteristics, lifestyle habits, exposure levels, and genetic diversity of xenobiotic-metabolizing enzymes involved in toluene metabolism in Korean and foreign workers exposed to toluene at a manufacturing plant. This study was conducted to determine the effects of culture or ethnicity on toluene metabolism. The results showed that blood and urinary toluene concentrations were dependent on the level of exposure to toluene. We analyzed the correlation between toluene metabolism and genetic diversity in glutathione S-transferase (GST) (M1), GSTT1, and cytochrome p-450 (CYP) 2E1*5 as well as lifestyle habits (smoking, drinking, and exercise habits). The results revealed significant correlations between toluene metabolism and GSTM1 and GSTT1 genetic diversity, as well as smoking and exercise.

Language: en