Citation

Lo Coco D, Militello A, Piccoli F, La Bella V. Acta Neurol. Scand. 2001; 104(4): 243-245.

Affiliation

ALS Clinic, Institute of Neuropsychiatry, via G. La Loggia 1, 90129 Palermo, Italy.

Copyright

(Copyright © 2001, John Wiley and Sons)

DOI

unavailable

PMID

11589655

Abstract

We report on a patient with bulbar-onset, clinically defined, sporadic amyotrophic lateral sclerosis (ALS) who also showed a Chiari I malformation. This malformation, otherwise asymptomatic, was detected during the diagnostic work-up for ALS. To our knowledge this is the first report of an association between these two relatively uncommon disorders. Since our patient worked for many years as a bus-driver and because the ALS symptoms began in the brainstem region, we suggest that his hindbrain anomaly, along with the mechanical stress on the spine and cranio-vertebral junction due to the daily driving, might have played a role in the region-specific onset of ALS.

Language: en