Citation

Chen D, Hale RC, Letcher RJ. Environ. Toxicol. Chem. 2015; 34(4): 687-699.

Affiliation

Cooperative Wildlife Research Laboratory and Department of Zoology, Southern Illinois University, Carbondale, Illinois, USA.

Copyright

(Copyright © 2015, Society of Environmental Toxicology and Chemistry (SETAC), Publisher John Wiley and Sons)

DOI

10.1002/etc.2858

PMID

25809099

Abstract

Among anthropogenic chemicals, flame retardants have attracted mounting environmental concerns. In recent years, an increasing number of studies have been conducted worldwide to investigate flame-retardant sources, environmental distribution, wildlife and human exposure, and toxicity. Data generated have demonstrated that some flame-retardant substances such as polybrominated diphenyl ethers (PBDE) are persistent, bioaccumulative, and toxic to exposed organisms. However, comparatively much less attention has been paid to the mechanisms and products of environmental transformation of flame retardants. This lack of information undermines our understanding of the environmental behavior and fate of flame retardants, as well as the associated risks to environmental and human health. Photochemical and microbial transformation of flame retardants in various matrices and environmental compartments can elevate the toxicological significance of flame retardant exposure, via the formation of, for example, lesser halogenated but more bioaccumulative degradation products and toxic radicals. Such pathways raise concerns related to the environmental safety of some alternative flame retardants that are presumably safe and used to replace PBDEs. To fully assess the environmental risks, more research is needed to investigate the environmental transformation potential of emerging flame retardants including polymeric flame retardants. Enhanced analytical efforts are needed to better characterize transformation products and transient radicals. Additional mesocosm and field studies are needed to elucidate transformation kinetics and consequences under environmentally relevant conditions. Environ Toxicol Chem 2015;34:687-699. © 2015 SETAC.

Language: en