Citation

Arain M, Khan M, Craig L, Nakanishi ST. Ann. Clin. Transl. Neurol. 2015; 2(3): 289-294.

Affiliation

Alberta Children's Hospital Research Institute, University of Calgary Calgary, Alberta, Canada ; Department of Biology, University of Hawai'i at Hilo Hilo, Hawai'i, USA.

Copyright

(Copyright © 2015, American Neurological Association, Publisher John Wiley and Sons)

DOI

10.1002/acn3.163

PMID

25815355

Abstract

Traumatic brain injury can cause persistent challenges including problems with learning and memory. Previous studies suggest that the activation of the cannabinoid 1 receptor after a traumatic brain injury could be beneficial. We tested the hypothesis that posttraumatic brain injury administration of a cannabinoid 1 receptor agonist can rescue deficits in learning and memory. Young adult male rats were subjected to a moderately severe controlled cortical impact brain injury, with a subset given postinjury i.p. injections of a cannabinoid receptor agonist. Utilizing novel object recognition and the morris water task, we found that the brain-injured animals treated with the agonist showed a marked recovery.

Language: en