Citation

Squara P. Comput. Math. Methods Med. 2014; 2014: 389845.

Affiliation

CERIC, Clinique Ambroise Paré, 27 boulevard Victor Hugo, 92200 Neuilly-sur-Seine, France.

Copyright

(Copyright © 2014, Hindawi Publishing)

DOI

10.1155/2014/389845

PMID

24738007

PMCID

PMC3966412

Abstract

The present review describes and validates a new ratio "S" created for matching predictability and balance between TP and TN. Validity of S was studied in a three-step process as follows: (i) S was applied to the data of a past study predicting cardiac output response to fluid bolus from response to passive leg raise (PLR); (ii) S was comparatively analyzed with traditional ratios by modeling different 2 ∗ 2 contingency tables in 1000 hypothetical patients; (iii) precision of S was compared with other ratios by computing random fluctuations in the same patients. In comparison to other ratios, S performs better in predicting the cardiac response to fluid bolus and supports more directly the clinical conclusions. When the proportion of false responses is high, S is close to the coefficient correlation (CC). When the proportion of true responses is high, S is the unique ratio that identifies the categorization that balances the proportion of TP and TN. The precision of S is close to that of CC. In conclusion, S should be considered for creating categories from quantitative variables; especially when matching predictability with balance between TP and TN is a concern.

Language: en