Citation

Jeong TO, Yoon JC, Lee JB, Jin YH, Hwang SB. J. Neuroimaging. 2015; 25(6): 1050-1052.

Affiliation

Research Institute of Clinical Medicine of Chonbuk National University, Emergency Medicine, Jeonju-si, Republic of Korea.

Copyright

(Copyright © 2015, Wiley)

DOI

10.1111/jon.12216

PMID

25682793

Abstract

Isolated and reversible lesion restricted to the splenium of the corpus callosum, known as reversible splenial lesion syndrome, have been reported in patients with infection, high-altitude cerebral edema, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Here, we report a 39-year-old female patient with glufosinate ammonium (GLA) poisoning who presented with confusion and amnesia. Diffusion-weighted magnetic resonance imaging of the brain revealed cytotoxic edema of the splenium of the corpus callosum. The lesion was not present on follow-up MR imaging performed 9 months later. We postulate that a GLA-induced excitotoxic mechanism was the cause of this reversible splenial lesion.

Language: en