Citation

Roten A, Baker NL, Gray KM. Addict. Behav. 2015; 45C: 119-123.

Affiliation

Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, 125 Doughty Street, Suite 190, MSC 861, Charleston, SC 29425, United States.

Copyright

(Copyright © 2015, Elsevier Publishing)

DOI

10.1016/j.addbeh.2015.01.013

PMID

25661990

Abstract

BACKGROUND: Adolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance.

METHODS: This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery.

RESULTS: Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores.

CONCLUSIONS: These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.

Language: en