Citation

Montenigro PH, Corp DT, Stein TD, Cantu RC, Stern RA. Annu. Rev. Clin. Psychol. 2015; 11: 309-330.

Affiliation

Chronic Traumatic Encephalopathy Center, Boston University School of Medicine, Boston, Massachusetts 02118 and Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118.

Copyright

(Copyright © 2015, Annual Reviews)

DOI

10.1146/annurev-clinpsy-032814-112814

PMID

25581233

Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is most often identified in postmortem autopsies of individuals exposed to repetitive head impacts, such as boxers and American football players. The neuropathology of CTE is characterized by the accumulation of hyperphosphorylated tau protein in a pattern that is unique from that of other neurodegenerative diseases, including Alzheimer's disease. The clinical features of CTE are often progressive, leading to dramatic changes in mood, behavior, and cognition, frequently resulting in debilitating dementia. In some cases, motor features, including parkinsonism, can also be present. In this review, the historical origins ofCTEare revealed and an overview of the current state of knowledge of CTE is provided, including the neuropathology, clinical features, proposed clinical and pathological diagnostic criteria, potential in vivo biomarkers, known risk factors, and treatment options. Expected final online publication date for the Annual Review of Clinical Psychology Volume 11 is March 28, 2015. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.

Language: en