Citation

Wang S, Blazer DG. Annu. Rev. Clin. Psychol. 2015; 11: 331-360.

Affiliation

Department of Psychiatry and Behavior Sciences, Duke University Medical Center, Durham, North Carolina 27710 and Durham Veterans Affairs Medical Center, Durham, North Carolina 27705; email: swang6@gmail.com.

Copyright

(Copyright © 2015, Annual Reviews)

DOI

10.1146/annurev-clinpsy-032814-112828

PMID

25581234

Abstract

This review provides an overview of the relationship between depression and cognition in the elderly, with an emphasis on psychotherapies and nonpharmacologic approaches. We first review the clinical presentation of late-life depression and comorbid cognitive impairment, as well as the epidemiology and risk factors for cognitive impairment in late-life depression and the temporal relationship between depression and cognitive impairment. Next, we discuss the salient topic of elderly suicide and cognitive impairment. Wethen touch briefly on the neuropsychological deficits, biomarkers, and neuroimaging findings in late-life depression with comorbid cognitive impairment. We then focus most of this review on psychotherapies and nontraditional treatments for late-life depression with comorbid cognitive impairment and examine what evidence, if any, exists of the cognitive and functional benefits of these treatments. Finally, we examine the cognitive effects of pharmacologic treatments and brain stimulation therapies. Expected final online publication date for the Annual Review of Clinical Psychology Volume 11 is March 28, 2015. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.

Language: en