Citation

Feliu C, Fouley A, Millart H, Gozalo C, Marty H, Djerada Z. Ann. Biol. Clin. (JLE) 2015; 73(1): 54-69.

Vernacular Title

Toxicologie clinique et analytique des opiacés, de la cocaïne et des amphétamines.

Affiliation

Laboratoire de pharmacologie et toxicologie, CHU de Reims, Reims, France.

Copyright

(Copyright © 2015, John Libbey Eurotext)

DOI

10.1684/abc.2014.1009

PMID

25582723

Abstract

In several circumstances, determination and quantification of illicit drugs in biological fluids are determinant. Contexts are varied such as driving under influence, traffic accident, clinical and forensic toxicology, doping analysis, chemical submission. Whole blood is the favoured matrix for the quantification of illicit drugs. Gas chromatography coupled with mass spectrometry (GC-MS) is the gold standard for these analyses. All methods developed must be at least equivalent to gas chromatography coupled with a mass spectrometer. Nowadays, new technologies are available to biologists and clinicians: liquid chromatography coupled with a mass spectrometry (LC/MS) or coupled with a tandem mass spectrometer (LC/MS/MS). The aim of this paper is to describe the state of the art regarding techniques of confirmation by mass spectrometry used for quantification of conventional drugs except cannabis.

Language: en