Citation

Tateno A, Sakayori T, Takizawa Y, Yamamoto K, Minagawa K, Okubo Y. Gen. Hosp. Psychiatry 2014; 37(1): 97.e7-970000009.

Affiliation

Department of Neuropsychiatry, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan. Electronic address: okubo-y@nms.ac.jp.

Copyright

(Copyright © 2014, Elsevier Publishing)

DOI

10.1016/j.genhosppsych.2014.09.016

PMID

25445070

Abstract

OBJECTIVE: To report a case of Alzheimer's disease (AD) following mild traumatic brain injury (TBI).

METHOD: Case report.

RESULTS: We report the time course of AD following mild TBI with evidence of AD pathology. A patient complained of minor memory disturbance 6 months after TBI and was diagnosed with mild cognitive impairment 1.5 years after TBI, and she was finally diagnosed as probable AD 4 years after TBI. Amyloid PET revealed brain accumulation of beta-amyloid at a pathological AD level.

CONCLUSION: Our case well illustrated how TBI can accelerate the AD process. Clinicians should carefully follow up patients with persistent cognitive impairment after TBI.

Language: en