Citation

Slegtenhorst BR, Dor FJ, Rodriguez H, Voskuil FJ, Tullius SG. Curr. Transplant Rep. 2014; 1(3): 147-154.

Affiliation

Division of Transplant Surgery and Transplant Surgery Research Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School.

Copyright

(Copyright © 2014)

DOI

10.1007/s40472-014-0017-6

PMID

25419507

Abstract

Ischemia/reperfusion injury (IRI), an inherent component of transplantation, affects organ quality and transplant outcomes. Although the complexity of the pathophysiology is recognized, detailed mechanisms remain unclear, and strategies preventing the consequences of IRI have been challenging. Of critical significance appears the link between IRI, the initiation of innate immune responses, and the (potential) augmentation of adaptive immunity. An improved understanding of those complex mechanisms and interactions may pave the way for more effective treatment strategies.

Language: en