Citation

Zitelli BJ, Alexander WRJ, Taylor S, Miller KD, Howrie DL, Kuritsky JN, Perez TH, Van Thiel DH. Ann. Intern Med. 1987; 106(3): 393-395.

Copyright

(Copyright © 1987, American College of Physicians)

DOI

unavailable

PMID

2949680

Abstract

Pyrimethamine-sulfadoxine has been associated with severe and fatal cutaneous reactions as well as transient liver damage. We report the case of a patient who died of progressive hepatic failure caused by pyrimethamine-sulfadoxine administration. In addition, we summarize reports made to the Food and Drug Administration since 1982 that focus on hepatotoxic reactions to pyrimethamine-sulfadoxine. We suggest that fatal hepatic injury can occur after treatment with pyrimethamine-sulfadoxine and that physicians who prescribe the drug should be aware of this possibility.

Language: en