Citation

Kim SW, Pentel PR. J. Toxicol. Clin. Toxicol. 1989; 27(6): 389-393.

Affiliation

Department of Psychiatry, Hennepin County Medical Center, University of Minnesota, Minneapolis 55455.

Copyright

(Copyright © 1989, Marcel Dekker)

DOI

unavailable

PMID

2628588

Abstract

The serotonin reuptake inhibitor zimelidine may cause flu-like symptoms and Guillain-Barre syndrome. Guillain-Barre syndrome has not been reported with the use of the structurally related serotonin reuptake inhibitor fluoxetine. Flu-like symptoms are described in the manufacturer's literature on fluoxetine but are absent from published studies. We describe a patient who developed flu-like symptoms, urticaria and angioedema 2 days after fluoxetine overdose. There were no neurologic sequelae. This case confirms that fluoxetine may be associated with flu-like symptoms and suggests that, because these symptoms occurred after overdose, they may be dose related. The additional findings in this patient suggestive of allergy, an unusual feature of drug overdose, are discussed.

Language: en