Citation

Lee S, Merriam A, Kim TS, Liebling M, Dickson DW, Moore GR. J. Neurol. Neurosurg. Psychiatry 1989; 52(3): 387-391.

Affiliation

Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, New York 10461.

Copyright

(Copyright © 1989, BMJ Publishing Group)

DOI

unavailable

PMID

2647908

PMCID

PMC1032416

Abstract

A selective subtotal cerebellar neuronal degeneration was found in a patient who died 4 1/2 months after suffering neuroleptic malignant syndrome (NMS), a rare, potentially fatal disorder associated with neuroleptic medications. It is suggested that the cerebellar neuronal degeneration in this case was due to hyperpyrexia, a cardinal clinical feature of NMS. Similar pathologic findings appear not to have been previously reported in NMS but have been described in heat-induced central nervous system (CNS) injury. The findings imply that a cerebellar syndrome might be encountered in patients who survive NMS complicated by a particularly high febrile course.

Language: en