Citation

Schmitt C, Kervégant M, Ajaltouni Z, Tauber M, Tichadou L, de Haro L. Arch. Pediatr. 2014; 21(11): 1213-1215.

Vernacular Title

Intoxication pédiatrique sévère avec une faible dose de clonidine : à propos d'un cas.

Affiliation

Centre antipoison de Marseille, hôpital Sainte-Marguerite, 270, boulevard Sainte-Marguerite, 13009 Marseille, France.

Copyright

(Copyright © 2014, Elsevier Publishing)

DOI

10.1016/j.arcped.2014.07.014

PMID

25284732

Abstract

Clonidine poisoning's clinical feature is well documented in the medical literature, but the minimal toxic dose has not yet been established. The effectiveness of naloxone is also controversial. The authors describe a clonidine overdose in a 9-year-old boy (25kg) during a growth hormone test: he received tenfold the prescribed clonidine dose (0.23mg instead of 0.023mg) with 6.2mg betaxolol. About 40min later, he became drowsy and then was found to have low blood pressure, bradycardia, and myosis. By maintaining the Trendelenburg position, administering fluids as well as salbutamol and naloxone (three doses of 0.2mg were required), he recovered and was discharged from the hospital on day 2. The minimal clonidine toxic dose, the clinical picture, and the effectiveness of naloxone administration are discussed in this paper.

Language: fr