Citation

Guo MY, Zhang SX, Xu MZ, Hu XY, Yang CJ, Chen WB. Nan Fang Yi Ke Da Xue Xue Bao 2014; 34(9): 1277-1281.

Affiliation

Department of Radiology, Guangdong General Hospital, Guangzhou 510000, China. E-mail: yingxiao315@163.com.

Copyright

(Copyright © 2014, Nanfang yi ke da xue xue bao bian ji bu)

DOI

unavailable

PMID

25263358

Abstract

OBJECTIVE: To investigate the changes in brain regional homogeneity in first-onset major depressive disorders (MDDs) using resting-state functional magnetic resonance imaging (fMRI).

METHODS: Eighteen patients with first-onset MDDs and twenty gender- and age-matched healthy controls underwent resting-state fMRI scans to compare the regional homogeneities of the brain regions.

RESULTS: Compared with the normal controls, the patients with MDDs showed significantly decreased regional homogeneity in the left posterior cingulated gyrus, bilateral inferior temporal gyrus, bilateral superior temporal gyrus, left inferior frontal gyrus, left hippocampa gyrus, left posterior central gyrus, left angular gyrus, right amygdala, right orbital frontal gyrus, right supplementary motor area, and right cerebellar lobe.

CONCLUSION: Patients with first-onset MDDs have dysfunctions in the brain regions closed related with cognition and emotional control.

Language: zh