Citation

Neuropsychology 2014; ePub(ePub): ePub.

Copyright

(Copyright © 2014, American Psychological Association)

DOI

10.1037/neu0000144

PMID

25244246

Abstract

Reports an error in "Eye movements reveal impaired inhibitory control in adult male fragile X premutation carriers asymptomatic for FXTAS" by Ling M. Wong, Naomi J. Goodrich-Hunsaker, Yingratana McLennan, Flora Tassone, Melody Zhang, Susan M. Rivera and Tony J. Simon (Neuropsychology, 2014[Jul], Vol 28[4], 571-584). References to "number of anticipatory saccades" in the prosaccade and antisaccade tasks should actually refer to "percentage of trials with anticipatory saccades." (The following abstract of the original article appeared in record 2014-15226-001.) [Correction Notice: An Erratum for this article was reported in Vol 28(4) of Neuropsychology (see record 2014-26868-002). In the Method section under the Participants subsection, the last two exclusion criteria for participants are distinct and should have been listed as two entities, separated by a semicolon: "history of alcoholism or drug problem; and use of medication that affects cerebral blood flow (e.g., current beta blockers)." Likewise, the authors wish to clarify that the dependent measure for the fixation behavioral task, in the Procedure subsection, was maximum gaze deviation from center during target presentation. Lastly, the last sentence in the Antisaccade task procedure section should read: "These were trials in which the initial saccade was in the same direction as the target."] Objective: Fragile X premutation carriers (fXPCs) have an expansion of 55 -200 CGG repeats in the FMR1 gene. Male fXPCs are at risk for developing a neurodegenerative motor disorder (FXTAS) often accompanied by inhibitory control impairments, even in fXPCs without motor symptoms. Inhibitory control impairments might precede, and thus indicate elevated risk for motor impairment associated with FXTAS. We tested whether inhibitory impairments are observable in fXPCs by assessing oculomotor performance.

METHOD: Participants were males aged 18-48 years asymptomatic for FXTAS. FXPCs (n = 21) and healthy age-matched controls (n = 22) performed four oculomotor tasks. In a Fixation task, participants fixated on a central cross and maintained gaze position when a peripheral stimulus appeared. In a Pursuit task, participants maintained gaze on a square moving at constant velocity. In a Prosaccade task, participants fixated on a central cross, then looked at a peripheral stimulus. An Antisaccade task was identical to the Prosaccade task, except participants looked in the direction opposite the stimulus. Inhibitory cost was the difference in saccade latency between the Antisaccade and Prosaccade tasks.

RESULTS: Relative to controls, fXPCs had longer saccade latency in the Antisaccade task. In fXPCs, inhibitory cost was positively associated with vermis area in lobules VI-VII.

CONCLUSION: Antisaccades require inhibitory control to inhibit reflexive eye movements. We found that eye movements are sensitive to impaired inhibitory control in fXPCs asymptomatic for FXTAS. Thus, eye movements may be useful in assessing FXTAS risk or disease progression. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

Language: en