Citation

Petraglia AL, Dashnaw ML, Turner RC, Bailes JE. Neurosurgery 2014; 75(Suppl 4): S34-S49.

Affiliation

*Department of Neurosurgery, Rochester Regional Health System, Rochester, New York; ‡Department of Neurological Surgery, University of Rochester Medical Center, Rochester, New York; §Department of Neurosurgery, The Center for Neuroscience, West Virginia University School of Medicine, Morgantown, West Virginia; and ¶Department of Neurosurgery, NorthShore University Health System, Evanston, Illinois and Department of Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, Illinois.

Copyright

(Copyright © 2014, Congress of Neurological Surgeons)

DOI

10.1227/NEU.0000000000000472

PMID

25232883

Abstract

: Mild traumatic brain injury (TBI) has become a rising epidemic, affecting millions of people each year. Even though it is the most common type of brain injury, our understanding of the science underlying mild TBI is just in its infancy. There has been an explosion of basic science research interest in mild TBI, as emerging clinical evidence is suggestive that concussion and subconcussion may result in detrimental long-term neurological sequelae, particularly when occurring repetitively. Many animal models have been developed to study the different pathological mechanisms implicated in TBI, and more recently there has been a heightened focus on modeling mild TBI in the laboratory as well. The most widely used models of TBI have been adapted for experimental mild TBI research, although more work still remains. The ability to create improved diagnostic measures and treatment approaches for concussion depend on the development and characterization of clinically relevant models of mild TBI. This review aims to provide a broad general overview of the current efforts to model mild TBI in animals and the challenges and limitations that exist in translating this behavioral, physiological, and anatomic knowledge from the bench to the clinical arena. ABBREVIATIONS:: CBF, cerebral blood flowCCI, controlled cortical impactCTE, chronic traumatic encephalopathyFPI, fluid percussion injuryLOC, loss of consciousnessMWM, Morris water mazeNSS, neurological severity scorePCI, projectile concussive impactTBI, traumatic brain injury.

Language: en