Citation

Stokbroekx MA, Houterman S, Coolen SAJ, van der Lely N, Pelleboer RA. Alcohol Alcohol. 2014; 49(6): 635-638.

Affiliation

Department of Paediatrics, Catharina Hospital, Eindhoven, the Netherlands r.pelleboer@onsnet.nu.

Copyright

(Copyright © 2014, Oxford University Press)

DOI

10.1093/alcalc/agu050

PMID

25227633

Abstract

AIMS: The aim of this study was to evaluate different carbohydrate-deficient transferrin (CDT) assays for the detection of recurrent excessive alcohol abuse in adolescents prior to acute alcohol intoxication.

METHODS: Data on drinking behaviour and CDT levels of adolescents (13-18 years) registered at the outpatient clinic for youth and alcohol at three major district general hospitals in the Netherlands were retrospectively collected. CDT and disialotransferrin (DST) levels of binge-drinking teenagers were compared with non-binge-drinking teenagers.

RESULTS: In total 198 samples were collected for the N Latex CDT method (N = 83), no differences were found in mean CDT levels for binge versus non-binge drinkers (P = 0.8). The Helander HPLC (N = 78) showed significantly higher values for binge drinkers than for non-binge drinkers (mean 1.20%DST, SD 0.28 and mean 1.01%DST, SD 0.31, respectively (P = 0.01)). The Recipe ClinRep method (N = 37) also showed significantly higher values for binge drinkers (mean 1.17%DST, SD 0.36 and mean 0.89%DST, SD 0.34, respectively (P = 0.03)).

CONCLUSION: With the Helander HPLC method and the Recipe ClinRep assay higher levels are measured in binge drinkers than in non-binge drinkers.

Language: en