Citation

De Smedt T, de Cremer K, Vleminckx C, Fierens S, Mertens B, Van Overmeire I, Bader M, De Paepe P, Göen T, Nemery B, Schettgen T, Stove C, Van Oyen H, Van Loco J, Van Nieuwenhuyse A. Toxicol. Lett. 2014; 231(3): 344-351.

Affiliation

Scientific Institute of Public Health, Department Public Health and Surveillance, Brussels, Belgium. Electronic address: an.vannieuwenhuyse@wiv-isp.be.

Copyright

(Copyright © 2014, Elsevier Publishing)

DOI

10.1016/j.toxlet.2014.09.009

PMID

25223249

Abstract

BACKGROUND: On Saturday May 4, 2013, a train transporting chemicals derailed in the village of Wetteren (Belgium) and caused a leak of acrylonitrile (ACN).

OBJECTIVES: To assess the human exposure to acrylonitrile in the local population with the highest suspected exposure.

METHODS: Between May 18-25, 242 residents participated in the study. N-2-cyanoethylvaline (CEV), a biomarker that is highly specific for ACN exposure, was measured in the blood. To account for potential influence by smoking, cotinine was determined in the urine. Participants also filled in a short questionnaire.

RESULTS: In the evacuated zone, 37.3% of the non-smokers and 40.0% of the smokers had CEV concentrations above the reference values of 10 and 200pmol/g globin, respectively, at the time of the train accident. Spatial mapping of the CEV concentrations depending on the residential address showed a distribution pattern following the sewerage system.

DISCUSSION AND CONCLUSION: The train derailment resulted in a highly atypical sequence-of-events. In addition to exposure in the direct vicinity of the site of the train derailment, exposure also occurred via the sewerage system, into which acrylonitrile had entered shortly after the accident.

Language: en