Citation

Henne-Bruns D, Artwohl J, Dziwisch L, Kremer B. Z Exp Chir Transplant Kunstliche Organe 1988; 21(5): 255-263.

Vernacular Title

Paracetamol-Intoxikation im Schweinemodell.

Affiliation

Chirurgische Universitätsklinik Hamburg.

Copyright

(Copyright © 1988)

DOI

unavailable

PMID

3195168

Abstract

In order to prove the function of isolated transplanted hepatocytes in acute liver failure we tried to establish a hepatic failure model in pigs which correlates to a clinical situation. In 12 pigs we administered 500-2000 mg/kg body weight acetaminophen after enzyme induction with Pentobarbital. 7 animals receiving 500-1000 mg/kg acetaminophen survived the intoxication, 5 animals receiving 1000-2000 mg/kg acetaminophen died within 6.5 hours after intoxication because of methemoglobinemia. A close correlation between administered dosage of the drug, acetaminophen blood levels and methemoglobinemia was found. Histology of surviving animals showed a dosage depended cell necrosis. A standardized hepatic failure model could not be established in pigs by acetaminophen intoxication, because dosages of more than 1000 mg/kg were survived. In dosage higher than 1000 mg/kg a side effect of the acetaminophen intoxication the methemoglobinemia limited the life of the animals. Therefore acetaminophen can not be used to induce acute hepatic failure in pigs.

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