Citation

Dørum G, Kling D, Baeza-Richer C, García-Magariños M, Sæbø S, Desmyter S, Egeland T. Int. J. Legal Med. 2014; 129(3): 411-423.

Affiliation

Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Aas, Norway, guro.dorum@nmbu.no.

Copyright

(Copyright © 2014, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s00414-014-1046-5

PMID

25108449

Abstract

Allelic dropout in relationship problems may commonly appear in areas such as disaster victim identification and the identification of missing persons. If dropout is not accounted for, the results may be incorrect interpretation of profiles, loss of valuable information and biased results. In this paper, we explore different models for dropout in kinship cases and present an efficient implementation for one of the models. The implementation allows for dropout to be handled simultaneously with phenomena like silent alleles and mutations that may also cause discordances in relationship data, in addition to subpopulation correction. The implemented dropout model is freely available in the new version of the Familias software. The concepts and methods are illustrated on real and simulated data.

Language: en