Citation

Hinrichs JV, Ghoneim MM. Psychopharmacology 1987; 92(1): 100-105.

Copyright

(Copyright © 1987, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

3110819

Abstract

Cognitive performance, psychomotor skills, and subjective reactions to diazepam and placebo were compared in 12 healthy, well-educated subjects in three age groups: 19-28, 40-45, and 61-73 years old. With only minor exceptions, the changes in performance caused by diazepam and age differences were statistically additive and noninteracting. Diazepam did not act synergistically in older individuals; the decrements in performance were about the same in all age groups. Baseline performance decreased with increasing age; middle-aged subjects performed more like older than younger subjects. A variety of tasks exhibited similar effects of aging and diazepam, i.e., when performance declined with increasing age, it was also reduced by diazepam.

Language: en