Citation

Giovagnoli AR, Parente A, Tarallo A, Casazza M, Franceschetti S, Avanzini G. Epilepsy Res. 2014; 108(8): 1461-1468.

Affiliation

Department of Diagnostics and Applied Technology, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy.

Copyright

(Copyright © 2014, Elsevier Publishing)

DOI

10.1016/j.eplepsyres.2014.06.002

PMID

25060995

Abstract

AIM OF THE STUDY: To compare the effects of perceived and assessed cognitive functions on quality of life (QoL) in patients with epilepsy (PWE).

METHODS: The study analyzed the data from a series of PWE who compiled the Quality of Life in Epilepsy-89 Inventory (QOLIE-89) and the Multiple Ability Self-Report Questionnaire (MASQ) for QoL and perceived cognitive abilities, respectively. The State-Trait Anxiety and Beck Depression inventories were used to assess mood. Neuropsychological tests evaluated abstract reasoning, attention, conceptual-motor tracking, constructional praxis, language, verbal and non-verbal memory, abstraction, category shifting, verbal fluency, and visual-spatial abilities.

RESULTS: The QOLIE-89 overall score was predicted by the Mood and Attention and Executive Functions factors and MASQ scores, explaining 38, 6, and 4% of its variance, while disease duration, seizure frequency, and schooling determined 16%. The QOLIE-89 Psychosocial, Cognitive, and Physical Performance sub-domains related to mood. The Cognitive and Physical Performance factors also related to the MASQ and Attention and Executive Functions factor scores, respectively.

CONCLUSIONS: In PWE, self-rated and assessed cognitive deficits may influence QoL, explaining 10% of its variance irrespective from mood and clinical variables. Treating cognitive deficits and their perception may help improve QoL.

Language: en