Citation

Tikhomirov SM, Bakharev VD. Probl Endokrinol (Mosk) 1986; 32(1): 46-49.

Vernacular Title

Psikhotropnye svoĭstva kortikotropina i ego analogov.

Copyright

(Copyright © 1986)

DOI

unavailable

PMID

3006019

Abstract

The authors presented evidence for the effect of 6 analogues of ACTN4-10 on teaching of albino rats in a labyrinth with negative electrocutaneous reinforcement. Sixteen series of experiments on 192 rats demonstrated a positive effect of corticotropin fragments on memory processes. The activating ACTH fragment effect was shown in recording the background and bioelectrically induced rabbit brain activity in response to a photo-flash in 36 experiments on 18 animals. Three groups of 30 patients with alcohol withdrawal syndrome, posttraumatic craniocerebral effect and schizophrenia received injections of corticotropin as a therapeutic agent. A high efficacy of corticotropin in the treatment of the alcohol withdrawal syndrome and after effect of craniocerebral injury and a low efficacy and sometimes aggravation of symptoms in schizophrenia patients were shown.

Language: ru