Citation

Schäfer K, Ukida M, Bode JC. Dtsch. Med. Wochenschr. 1982; 107(22): 860-864.

Vernacular Title

Aminosäurenkonzentration im Plasma bei Lebernekrose nach Tetrachlorkohlenstoffvergiftung.

Copyright

(Copyright © 1982, Georg Thieme Verlag)

DOI

10.1055/s-2008-1070035

PMID

7084051

Abstract

Three men (aged 29 to 36 years) were admitted after swallowing 20-40 ml of carbon tetrachloride-containing liquid. On admission the Quick values were between 15 and 45%, maximal transaminase values 1900-5500 U/1. Acute renal failure occurred, requiring dialysis in two. In addition to the usual biochemical values, daily plasma concentrations of 18 amino acids were determined. The concentrations of phenylalanine, tyrosine, methionine, valine, leucine, ornithine and lysine were definitely elevated in the first 2-12 days. Except for glycine, tryptophan and arginine, the other aminoacids were slightly or definitely elevated for two to six days in two of the patients. Arginine concentrations were extremely low in the first two days. This shift in the pattern of plasma aminoacids in patients with carbon tetrachloride poisoning largely corresponds to those with severe acute liver necrosis of other aetiology and in part differ from the aminoacid pattern observed in animal experiments.

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