Citation

Mallach HJ, Schaffer A, Schenzle D, Dietz K. Blutalkohol 1982; 19(3): 211-228.

Copyright

(Copyright © 1982, International Committee on Alcohol, Drugs and Traffic Safety and Bund gegen Alkohol und Drogen im Straßenverkehr, Publisher Steintor Verlag)

DOI

unavailable

PMID

unavailable

Abstract

In a combination field comprising 9 cells, each of which contained 5 subjects, doses of 25 and 50 mg trazodone as well as 0.6 and 1.25 g alcohol/kg bodyweight singly as well as combined were given orally and their effect investigated on the kinetics and activity of both substances. According to our experiments on healthy subjects alcohol has a definite effect on the speed of absorption of trazodone; in low doses this takes the form of an acceleration and in higher doses of a retardation. Apart from this trazodone does not alter the renal elimination of alcohol. Due to technical difficulties it was not possible to test whether alcohol had a similar effect on the elimination of trazodone. Based on the results obtained so far the original psychophysical state is changed by trazodone and/or alcohol. The main symptoms are sickness, nausea and sometimes continuous vomiting as well as prolonged tiredness and falling asleep. Associated with this is a reduction in the reaction capacity.