Citation

Besnard T, Sadeg N, Ricart N, Richecœur J, Nisse P, Vinner E, Houdret N, Humbert L, Lhermitte M. Acta Clin. Belg. 2002; 57(Suppl 1): 8-11.

Vernacular Title

Determination serique de la crimidine par clhp/es/sm chez un patient ayant ingere un " souricide foudroyant "

Affiliation

Unité Fonctionnelle de Toxicologie, Laboratoire de Biochimie et de Biologie Moléculaire, CHRU de Lille-59037 Lille Cedex.

Copyright

(Copyright © 2002, Maney Publishing)

DOI

10.1179/acb.2002.069

PMID

24862517

Abstract

Crimidine (2 chloro, 4 methyl, 6 dimethyl amidopyrine) is a synthetic rodenticide which causes acute poisonings after oral ingestion in human. Major toxic effects are consciousness disorders, hypertonic coma and convulsions. Toxic level in human is about 5 mg/Kg. An intoxication case is reported. Five serums collected at different times were analyzed with HPLC/ ES/MS. Crimidine was extracted with ethylacetate with recovery over 80 %. Linearity was up to 800 μg/L. LOQ and LOD were 0.5 and 0.3 μg/L respectively. The coefficients of variation were less than 10 % for repeatability and reproductibility. Serum levels varied from 368 μg/L for H0 to 64 μg/L for H10 and elimination of crimidine was linear in time.

Language: en