Citation

Nisse P, Deveaux M, Tellart AS, Dherbecourt V, Peucelle D, Mathieu-Nolf M. Acta Clin. Belg. 2002; 57(Suppl 1): 12-15.

Affiliation

Centre antipoison de Lille, CHRU, 5 avenue Oscar Lambret F - 59037 LILLE cedex, France Tél. : + 33 (0) 3 20 44 55 62, Mél : p-nisse@chru-lille.fr.

Copyright

(Copyright © 2002, Maney Publishing)

DOI

10.1179/acb.2002.070

PMID

24862518

Abstract

Among the 2 726 cases of human pesticide poisoning collected at the Poison Centre of Lille from January 1998 to May 2001, 39 cases were related to the ingestion of aldicarb. Analysis of the circumstances found a suicide attempts in 33 cases and an accidental ingestion in 6 cases. The sex-ratio was 31 men for 8 women, mean age was of 36,6 years (15 months - 77 years). Thirty one poisoning were symptomatic with muscarinic signs (20 cases), digestive (15 cases), neurological ( 8 cases), nicotinic signs (6 cases). Treatment was based on digestive evacuation (14 cases), administration of activated charcoal (14 cases), atropine (7 cases), pralidoxime (1 case), preservative vital functions by intubation and ventilation (7 cases). Sedation was necessary in 4 cases. Hospitalization was necessary in 34 cases. The Poison Severity Score was estimated at 0 (any gravity) in 5 cases, 1 (weak) in 12 cases, 2 (moderate) in 7 cases, 3 (severe) in 8 cases and 4 (lethal) in 2 cases. In one of deaths, aldicarb was determined by HPLC-DAD in blood (6,04 μg / ml), urines (1,88 μg / ml) and gastric contents (3,98 μg / ml). These concentrations are the most important ever described in the litterature. Aldicarb is the most toxic carbamate insecticide for human.

Language: en