Citation

Amberg R, Furmaier R, Hirt H, Urban R. Blutalkohol 2002; 39(2): 61-71.

Affiliation

Amberg, R., D-79098 Freiburg, Germany

Copyright

(Copyright © 2002, International Committee on Alcohol, Drugs and Traffic Safety and Bund gegen Alkohol und Drogen im Straßenverkehr, Publisher Steintor Verlag)

DOI

unavailable

PMID

unavailable

Abstract

In four cases the local brain ethanol concentrations were investigated by means of magnetic resonance spectroscopy in vivo after intra venous application of 0.4-0.6 ethanol/kg body mass. It was observed that there were different brain ethanol concentrations in different parts of the brain - in the basal ganglia, the Para ventricular region and the cerebellum - during ethanol influx with time intervals of 5 minutes, measured at time spans of approximately 6 minutes. The results were confirmed by PET investigation after continuous infusion and bolus injection of 1 lc labelled ethanol at time intervals of 6 to 40 minutes. The possible reasons for this initial uneven distribution in the brain are discussed on the basis of literature on animal experiments and associated studies of ethanol and receptor complexes of the GABA-BZ-receptor and the NMDA-receptor systems.