Citation

Barnett G, Licko V, Thompson T. Psychopharmacology 1985; 85(1): 51-56.

Copyright

(Copyright © 1985, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

2984710

Abstract

Male volunteer subjects smoked one marijuana cigarette containing 100, 200, or 250 micrograms/kg delta-9-tetrahydrocannabinol (THC) and were tested on three perceptual-motor performance measures related to driving. Performance was measured and blood samples were collected for 24 h after smoking. The covariation between pharmacodynamics of performance and pharmacokinetics of THC in plasma was investigated for decrement in performance as the response to smoking a single marijuana cigarette. A significant linear correlation was found between tracking errors under divided attention and THC plasma levels over 5-25 ng/ml for approximately 2 h after smoking. A sigmoid relation was found between critical tracking breakpoint and log THC plasma levels over 2-25 ng/ml for approximately 7 h after smoking.

Keywords: Cannabis impaired driving

Language: en