Citation

Weber M, Schulz H. Toxichem Krimtech 2013; 80(Spec Iss): 284-287.

Copyright

(Copyright © 2013, Gesellschaft für Toxikologische und Forensische Chemie)

DOI

unavailable

PMID

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Abstract

Different developed methods for determination of warfare agents allow the examination of water samples but also of complex matrices such as food, biological and environmental samples. The methods allow the estimation of toxicity of samples. Nerve agents are determined enzymatically on the inhibitory effect on acetylcholinesterase. Sulfur mustard can be determined photometrically after alkylation of a pyridine derivative. Lewisite is determined by gas chromatography after derivatization with ethanethiol. Ricin is determined immunologically by a lateral flow assay. The detection limit for all nerve agents in aqueous samples is 0.1 μg/l, for mustards 20 μg/l, for lewisite 50 μg/l. For ricin a detection limit of 50 μg/l can be achieved, with enrichment procedure a detection limit of 1 μg/l is possible.

Language: en