Citation

Gorantla JN, Vellekkatt J, Nath LR, Anto RJ, Lankalapalli RS. Nat. Prod. Res. 2014; 28(18): 1507-1512.

Affiliation

a Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110 001 , India.

Copyright

(Copyright © 2014, Informa - Taylor and Francis Group)

DOI

10.1080/14786419.2014.913242

PMID

24805359

Abstract

We report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of Cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. Derivatives 2a-j were evaluated for cytotoxicity towards five human cancer cell lines of different origins, namely SKBR3 (breast), HeLa (cervical), A375 (skin), HepG2 (liver) and HCT-116 (colon), and IC50 values were determined. Derivatives 2b and 2h exhibited moderate cytotoxicity against HCT-116 and A375 cell lines, respectively.

Language: en