Citation

Long CL, Birkhahn RH, Geiger JW, Blakemore WS. Am. J. Clin. Nutr. 1981; 34(6): 1087-1093.

Copyright

(Copyright © 1981, American Society of Clinical Nutrition)

DOI

unavailable

PMID

7234737

Abstract

Whole body protein breakdown using 15N and skeletal muscle protein breakdown from urinary 3-methylhistidine were measured simultaneously in seven skeletal trauma and eight normal subjects on a standard hypocaloric, protein free diet. The trauma group had a 31% greater resting metabolic energy expenditure than controls. The control males lost 3.73 mumol/kg/day of 3-methylhistidine which suggested a protein breakdown rate of 0.89 g P/kg/day. The control females lost 2.46 mumol/kg/day of 3-methylhistidine or a breakdown rate of 0.58 g P/kg/day. These parameters were 187% greater for males and 163% greater for females in the trauma group. The measured whole body protein breakdown rates were 3.64 g P/kg/day for the control males and 2.69 for females. Skeletal trauma increased both by 73%. Skeletal trauma raised the muscle contribution to the whole body breakdown rate from 24.4 to 40.4% for men and from 21.6 to 33.0% for women. This disproportionate increase in muscle protein breakdown is consistent with muscle protein metabolism being most seriously affected by severe injury.

Language: en