Citation

Nexø E, Hollenberg MD, Bing J. Acta Physiol. Scand. 1981; 111(3): 367-371.

Copyright

(Copyright © 1981, John Wiley and Sons)

DOI

10.1111/j.1748-1716.1981.tb06749.x

PMID

7032211

Abstract

The plasma concentration of epidermal growth factor (EGF) in normal, nephrectomized and sialectomized mice is about 0.5 nmol/l. Aggressive behaviour results in a parallel increase in both plasma EGF and plasma renin for both normal and nephrectomized mice. The plasma concentration of EGF increases around 300- and 150-fold respectively; no increase is observed in sialectomized mice, suggesting that the submaxillary gland is an important source of liberated EGF. Virtually all the EGF is found in plasma as a low molecular species that behaves as pure EGF, when examined by radioimmuno- and radioreceptor assays.

Language: en